Benzodiazepines (commonly referred to as benzos) are a class of psychoactive substances that act as central nervous system depressants. These substances work by magnifying the efficiency and effects of the principal inhibitory neurotransmitter gamma-aminobutyric acid (GABA) by binding to and acting on its receptors.
The pharmacological properties of the compounds prepared initially were disappointing, and Sternbach abandoned the project. The first benzodiazepine, chlordiazepoxide ( Librium ), was synthesized in 1955 by Leo Sternbach while working at Hoffmann–La Roche on the development of tranquilizers.
The characteristic effects of benzodiazepines include anxiety suppression, sedation, muscle relaxation, disinhibition, sleepiness and amnesia. In a medical context, short-acting benzodiazepines are typically recommended for treating insomnia or acute anxiety or panic attack disorders while long-acting ones are recommended for the treatment of generalized anxiety disorders.
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It compared benzodiazepines when used alone as the only medication or when used in combination with another drug for people with schizophrenia. Information from the 34 studies was generally poor, incomplete and badly reported. The 34 studies were of short duration and were small in size. The review suggests that.
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They cause sedation, calmness and relax the muscles, so are helpful in calming down agitated people with anxiety, sleep problems, seizures, alcohol withdrawal and acute mental health problems. Benzodiazepines can be taken alone or in combination with more traditional antipsychotic drugs.
No.: CD006391. Art. Link to Cochrane Library. Cochrane Database of Systematic Reviews 2012, Issue 11.
There are more than 15 different types of FDA-approved benzodiazepine medications. These drugs are referred to as benzos and are widely prescribed for a variety of medical and mental health concerns. PsychCentral reports that the benzodiazepine drug Xanax was the mostly widely prescribed psychiatric medication.
30 May 2017. Web. “Top 25 Psychiatric Medication Prescriptions for 2013.” Psych Central. 17 Jul 2016.
Benzodiazepines are short-, intermediate-, or long-acting. Short-acting benzodiazepines include the following:. Longer-acting medications take longer to begin working and stay longer in a person’s system. Drugs with shorter half-lives work rapidly and leave the system faster.
There are more than 15 different types of FDA-approved benzodiazepine medications. PsychCentral reports that the benzodiazepine drug Xanax was the mostly widely prescribed psychiatric medication from 2005 to 2013.
Benzodiazepine, any of a class of therapeutic agents capable of producing a calming, sedative effect and used in the treatment of fear, anxiety, tension, agitation, and related states of mental disturbance. The benzodiazepines are among the most widely prescribed drugs in the world. The first.
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Some are used primarily as sleeping pills (hypnotics)…. The development of chlordiazepoxide was followed by a large variety of benzodiazepines, each with slightly different properties. The first to be discovered was chlordiazepoxide (Librium), in 1959. The benzodiazepines have become the drugs of choice for acute anxiety.
Newer and safer medications are…. The azapirones (e.g., buspirone) have little potential for producing dependency and are not affected by alcohol intake.
More than 30 percent of overdoses involving opioids also involve benzodiazepines, a type of prescription sedative commonly prescribed for anxiety or to help with insomnia. In 2015, 23 percent of people who died of an opioid overdose also tested positive for benzodiazepines (see.
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This page was last updated September 2017.
Revised September 2017.
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In a study of over 300,000 continuously insured patients receiving opioid prescriptions between 2001 and 2013, the percentage of persons also prescribed benzodiazepines rose to 17 percent in 2013 from nine percent in 2001.